Fibrinogen fragments and platelet dysfunction in uremia

Autonomic dysfunction in uremia.

Autonomic nervous system dysfunction is a common feature in uremia and may have a number of clinical sequelae. Simple cardiovascular reflex screening can be performed in patients during conservative treatment, on periodic dialysis therapy, or after kidney transplantation to diagnose and follow up autonomic function impairment. Other approaches, such as heart-rate variability studies in the freq...

Platelets and Platelet Phosphatides in Uremia

By Gsaw n ALTSCHULER, AARON J. MARcus AND H uims L. Uu i N I HE HEMORRHAGIC tendency which develops in uremia is a well recognized clinical entity but the pathogenesis of this complication is not understood.’ In the past defective blood coagulation2 as well as increased vascular fragility3 have been suggested. The possibility of a functional blood platelet abnormality was first noted by Lewis, ...

Platelet Function and Factor VIII in Uremia*

Platelets and platelet phosphatides in uremia.

By Gsaw n ALTSCHULER, AARON J. MARcus AND H uims L. Uu i N I HE HEMORRHAGIC tendency which develops in uremia is a well recognized clinical entity but the pathogenesis of this complication is not understood.’ In the past defective blood coagulation2 as well as increased vascular fragility3 have been suggested. The possibility of a functional blood platelet abnormality was first noted by Lewis, ...

Neutrophil apoptosis and dysfunction in uremia.

The high prevalence of bacterial infections among patients with end-stage renal disease suggests that "professional" phagocytes such as neutrophils are functionally impaired. This dysfunction has been ascribed to uremic toxins, malnutrition, and dialysis. The aim of this study was to investigate the contribution of apoptosis to neutrophil dysfunction in uremia. Neutrophils harvested from uremic...